Application for Augusto Odone New Investigator Award

INSTRUCTIONS: - Adobe Acrobat Professional version 8.0 or higher is recommended.

Form Page 1

Title of Project – give a brief descriptive title of the proposed work

NAME – Name of the applicant

DEGREE – Highest degree held by applicant

TITLE – Job title (e.g. Research Assistant Professor, Instructor, etc.) held by applicant on date of award activation (Sept 15, 2009)

Date of Appointment – Date on which applicant was appointed to the position held on the date of award activation.

Institution – Institution where applicant holds position on date of award activation

Human Subjects – If the proposal involves human subjects, please state the tracking number assigned by the Institutional Review Board (IRB) , the date on which the IRB received the protocol. Protocols involving human subjects must receive IRB approval before activation of the award.

Vertebrate Animals – If the proposal involves vertebrate animals, please state the tracking number assigned by the Institutional Animal Care and Use Committee (IACUC) and the date on which the IACUC received the protocol. Protocols involving animal subjects must receive IACUC approval before activation of the award.

Administrative Officer Signing for Institution - Signature of applicant’s Department Chair, or Dean, or equivalent, who assumes administrative oversight.

Fiscal Officer Signing for Institution – Signature of person assuming fiscal responsibility for grant funds.

Form Page 2

Project Summary – Please summarize your proposed work. Include a brief background, a statement of the hypothesis to be tested, the specific aims to address the hypothesis, and the anticipated results. Please do not exceed the allotted space

Relevance to Adrenomyeloneuropathy – Please state how the proposed work will advance the treatment of adrenomyeloneuropathy. Please do not exceed the allotted space.

Summary of Project for Non-Professionals – Please summarize the proposed work in laymen’s language (10^th grade reading level or lower). This section will be used when the notice of award is announced in the press. Please do not exceed the allotted space

Performance Site – If this is the same as the INSTITUTION on page 1, write SAME in the Organizational Name box. If this is different from the INSTITUTION listed on page 1, please state the name and address of the co-operating institution.

Form Page 3

Detailed Budget – Please state the budget in U.S. dollars for the first year of the proposal, using the categories listed. Salary for the PI is limited to 15% of the annual salary. Please note that Institutional Overhead is NOT allowed by The Myelin Project or by Olivers Army.

Form Page 4

Budget Justification – Please justify the amount for each of the categories listed in the detailed budget. Use additional pages as necessary; pages should be numbered 4b, 4c, 4d etc.

Form Page 5

Biographical Sketch – Please supply the information requested for the Principal Investigator and each senior person (postdoctoral or equivalent and above) listed in the Budget and Budget Justification. Please do not exceed three pages for each person. Please number the pages 5a, 5b, 5c, etc.

Form Page 6

Resources – For each category, please describe the institutional resources available to the applicant. Be specific with regard to laboratory and office space, clinical and/or animal space, secretarial/support staff and availability of shared equipment. Pages should be numbered 6a, 6b, 6c, etc.

Form Page 7

Other Support – Please supply the requested information for the Principal Investigator and each senior person (postdoctoral or equivalent and above) listed in the Budget and Budget Justification. Additional pages must adhere to the format provided, and should be numbered 7a, 7b, 7c, etc.

Pages 8 through 15

Research Plan – It is recommended that this section be prepared in a word-processing program, then converted to a PDF file and attached to the form pages. The name of the applicant must appear in the upper right hand corner of each page, and the pages must be numbered consecutively, beginning with page 8. The research plan must be typed in a font that has no more than 15 characters per linear inch (6 characters per cm), with no more than 6 lines per vertical inch, and no more than 57 lines per page. Top and bottom margins should be at least 2 cm, and side margins at least 1.5 cm. Proposals that exceed these limits will be returned without review. Recommended fonts include Ariel 12 point, Times 12 point or Times Roman 12 point. The proposal must contain these subheadings, and observe these space limits:

Specific Aims – State the hypothesis that is to be tested, the specific aims addressed by the proposed work, and a brief rational for the chosen approach. One-half page limit (about 30 lines). 

1. Background and Significance – State how the proposed work fits with what has been done in other laboratories. Do not exceed 1 1/2 pages (about 84 lines)
2. Preliminary Data – Review any data from the PI’s laboratory that is relevant to the proposed work, and which suggests that the proposed experiments will garner interpretable results. All graphs tables and figures must be placed next to the appropriate text. Each graph, table and figure must be clearly labeled, with a legend that is of the same font size as the text. Do not exceed 3 pages, including graphs tables and figures. 
3. Research Design and Methods – Describe the experiments that will be performed to address each of the specific aims. Give a rationale for each series of experiments, state the anticipated outcomes, and describe alternative approaches. All graphs tables and figures must be placed next to the appropriate text. Each graph, table and figure must be clearly labeled, with a legend that is of the same font size as the text. Do not exceed 5 pages, including graphs, tables and figures.
4. Timeline – Please give an estimate of how long each of the proposed experimental series will require, and an approximate order in which the experiments will be done. It is recommended that this section not exceed 1/2 page
5. Literature Cited – Give a full reference (all authors, full title of reference, journal volume, inclusive pages and year) for all published work cited in the proposal. There is no page limit for this section.
6. Protection of Human Subjects – Please state how the research protocol for human subjects (if any) will meet and comply with the relevant national and international laws regarding protection of human subjects. Please state the precautions to be taken to ensure the privacy of each subject. There is no page limit for this section.
7. Protection of Animal Subjects – please state how the research protocol for vertebrate animals (if any) will meet and comply with the relevant laws regarding use of laboratory animals. There is no page limit for this section.

APPENDIX

1.   Electronic copies of up to three publications by the PI that are relevant to the proposed work.

2.   A signed letter of support from any collaborating investigators, written on Institutional letterhead.

3.   A letter from the applicant’s department chair (or equivalent), stating that the applicant holds (or will hold at the time of award activation) an independent research or academic track position.