The objective of the Scientific Advisory Committee of The Myelin Project is to review research proposals put forth to our organization in order to determine whether or not the research is viable from a medical and scientific perspective. They serve solely as advisers, have no special interest in our organization, nor are they compensated for their efforts. They serve strictly as an advisory committee to aid our organization in making wise funding decisions toward practical research and clinical studies.
University of Wisconsin, USA
The core research area of this laboratory is myelin. Myelin is the insulator of axons and is essential for normal impulse transmission in the nervous system. We are interested in both the development of myelin in the central nervous system (CNS) and how myelin is targeted in acquired disorders of the CNS, in particular in multiple sclerosis (MS). To explore both development and disease of myelin, we use a variety of models, including animals with mutations in myelin genes (the myelin mutants), to study both the genetic control of myelin formation and maintenance and myelin repair. We are especially interested in cells that could be transplanted into the CNS to repair areas of myelin disease.
University of Edinburgh, UK
Charles ffrench-Constant’s lab seeks to answer questions in regenerative biology by following three lines of research. By studying oligodendrocyte biology and myelination, we hope to identify basic principles with the lo
Yale University, USA
Dr. Jeff Kocsis has shown that stem cells derived from adult human bone marrow when transplanted into experimental demyelinating lesions, produce a significant improvement in functional outcome. They do this by stimulating new myelin formation. Research Interests: Transplantation-based approaches toward restoration and preservation of function in the injured central nervous system; Axonal Regeneration; Cell Transplantation; Ion Channels; Nerve Injury; Remyelination; Spinal Cord Injury.
University of Cambridge, UK
Dr. Robin Franklin’s group at the University of Cambridge have been working on the idea that the brain contains a population of endogenous stem cells or progenitors that can be recruited to become myelinating cells in MS, and possibly other myelin disorders. They have identified some key molecules that might be used in future clinical trials, to promote ‘host’ repair.
University of Göttingen, GERMANY
Dr. Brück has been studying the immunopathology of MS lesions in attempts to unravel the mechanisms behind endogenous remyelination. It appears that in MS lesions, sufficient myelin-forming precursor cells are present but they do not differentiate into mature cells.
San Raffaele Hospital, ITALY
Dr. Gianvito Martino’s lab (San Raffaele Hospital) has been working in the field of stem cell biology, particularly neural stem cells. They have shown that these cells, when transplanted into models of MS, have marked effects on the immune system and help protect against neurodegeneration. The goal is to take this approach into clinical trials.
L’hopital de la Salpetriere, FRANCE
In Paris, Dr. Anne Baron Van Evercooren (L’hopital de la Salpetriere) and her colleagues have been involved in studying remyelination, both by transplanted cells (exogenous) and by host cells (endogenous). They have worked both with myelinating cells from the peripheral nervous system and central nervous system. They have shown activation of neural stem cells from key areas of the CNS in animal models and in the brain of MS patients. They have also evaluated the biological properties of human fetal neural precursors on transplantation into animals.
Stanford University, USA
Keith approach’s even the most complex patients with the understanding that while few disorders are “curable”, all disorders are treatable. Van Haren works closely with a team of dedicated, rigorous multi-disciplinary specialists to provide a comprehensive approach to complex neurological care. Their goal is to increase both the quality and the duration of life for children and adults affected by serious neurological disorders.