Discover the science of the human brain


What are they? How will they help you? 

When you hear the term “nootropics”, think substances that make your brain perform better and faster. They are able to open your neurological pathways in ways that you have never experienced before.

Whether you are in college and you need a boost that will enable you to quickly assimilate whatever the boring professor has been talking about all semester or belong to the working class thriving to give your best to every task assigned to you, nootropics are here to save the day.

Nootropics go by several names, some of which are smart drugs, brain pills, and cognitive enhancers. They all perform one function: boost brain power. These drugs are available as prescription pills or over-the-counter dietary supplements.

The focus here will be the best nootropics available over the counter in the U.S.

The Best Cognitive Nootropics and Smart Drugs Today

1. NooCube

Noocube bottle

In the race for the number nootropic spot, NooCube comes first due to its effectiveness and safety. 

It has no known side effects

For older adults and people suffering from Alzheimer’s, dementia, premature brain aging, and brain damage, no other natural nootropic supplement available today does it better than NooCube.

NoocCube is well known for its superb ability to improve and restore damaged brain cells, making it perfect for older adults above age 50.

How is NoocCbe Able to achieve this feat?

With only seven natural ingredients that stack to stimulate the different neurotransmitters in the user’s brain, it can optimize brain performance and that is what people look for a product like this one. 

Apart from its healing abilities, NooCube can also improve focus, learning ability and enhance a person’s communication skills. More icing on the cake.

NooCube is gluten and caffeine-free, so people on a health-kick won’t feel unhealthy taking the product. Moreover, it is a GMO-free brain supplement approved by the FDA, meaning science and government is backing the claims.

Ingredients List

  • Alpha Glycerylphosphorylcholine (Alpha GPC)
  • Huperzine A
  • Cat’sCat’s Claw (Uncaria tomentosa)
  • Bacopa Monnieri
  • Oat straw
  • L-Tyrosine
  • L-theanine

Possible Side Effects

One downside us the side effect linked to the presence of the Huperzine A ingredient, in which clinical trials showed stomach pains, headache, mood swings, and dizziness.

NooCube is not recommended to be used by breastfeeding and pregnant women. People below the age of 18 are also advised to stay off this pill.

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2. Mind Lab Pro

Mind Lab Pro bottle

Mind lab pro is manufactured by neuroscientists who have taken time to perform their in-house research. They know what natural herbs, amino acids, and vitamins your brain needs to be on top performance.

Ingredients list

  • Sharp-PS Green (Phosphatidylserine).
  • Cognizin (citicoline),
  • Suntheanine (l-theanine)
  • Bacopa Monnieri
  • Lion’sLion’s Mane mushroom
  • Rhodiola Rosea
  • Vitamin B6
  • Vitamin B9
  • Vitamin B12
  • N-Acetyl L-Tyrosine
  • Maritime pine Bark Extract

Who Needs Mind Lab Pro?

  1. If you are battling mood swings, lack the willpower to get stuff done quickly, or struggle with procrastination, Mind Lab Pro will boost your drive to get your work done at the right time.
  2. For people who struggle to concentrate and tend to be easily distracted. 
  3. For people suffering with brain fog and want to increase brain processing speed, brain energy boost, and better mental clarity.

How can this nootropic supplement do all this, you may ask? 

Mind lab pro combines the right stack of ingredients that work together to feed your brain cells just what they crave, thereby fostering faster regeneration ability and increasing the flow of oxygen and nutrients to the brain.


To put your mind at ease, all you patriotic people will be pleased to know that this nootropic supplement is manufactured in the U.S.A.

In addition to being manufactured in the U.S, Mind Lab Pro nootropic has also undergone several tests that assure users of the ingredients’ quality. It is also FDA-approved, and the facility used in the manufacture of the Mind Lab Pro-brain supplements are GMP certified, which means this substance is not only safe but also made using very pure ingredients.

You do not have to worry about the side effects of caffeine, artificial coloring, and artificial flavors. It is 100% natural and vegan-friendly for people concerned about what they are putting in their bodies. 

Everyone who uses Mind Lab Pro has less reason to worry since there are no allergens like fish, peanut, soy, egg, dairy, and shellfish. The capsule caps are derived from natural vegan plants and not semi-synthetic polymers like many other pills in the market today.

Nootropic stacks present in Mind Lab Pro

  • Citicoline + Rhodiola Rosea are known to boost brain energy
  • Rhodiola Rosea + Phosphatidylserine fight off stress
  • Maritime Pine Bark Extract + Lion’sLion’s Mane mushroom keeps the brain healthy
  • L-Theanine + Vitamin B6, Vitamin B9, Vitamin B12 work to keep the brain calm and prevent mood swings.
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3. Performance Lab Mind

Performance Lab Mind bottle

Performance Lab Mind stands out due to its short and precise ingredients list.

The company eliminates any unnecessary ingredients while giving you the accurate nootropic ingredients stack that will provide you with the brainpower boost you desire. 

Additional benefits that you can enjoy with this nootropic are increased focus and brain speed.

Ingredients list

  • Citicoline as cognizin
  • Sharp-PS Green (phosphatidylserine).
  • Ajipure Tyrosine
  • Maritime Pine Bark Extract (95% extract)

With these four ingredients, Performance Lab Mind can boost your energy, lower stress levels, and make sure your logical thinking cap is on all the time to help breeze through homework or play Chess better. 

All these benefits are possible since the four ingredients present are the most essential to increasing cognitive brain function.

Although Performance Lab Mind and Mind Lab Pro are made by Opti-Nutra, a little difference is noticed in these two natural supplements.

  • Performance Lab Mind is less expensive and has a more compact ingredients list.

The performance lab mind, like its older sibling (Mind Lab Pro), is also manufactured using the strictest standards. It is FDA-approved, and GMP certified.

However, the Performance mind lab nootropic is not as potent as Mind lab pro. It lacks essential B vitamins like vitamin B12 present in the mind lab pro. Either way, it is entirely natural and very vegan-friendly. It is also non-irradiated and gluten-free. Caffeine, allergen, and synthetic additives are all excluded in the manufacture of this brain-boosting supplement.

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4. Qualia Mind

Qualia Mind bottle

If you want to stay focused on a given task for longer periods, then look no further than Qualia Mind. This supplement helps you with decision-making as it combines the finest stack of ingredients that increases willpower.

This pill is 100% natural, gluten-free, non-GMO. It contains no artificial colors, flavors, or sweeteners, so you will unlikely experience side effects.

A short pilot study carried out by Neurohacker Collective, the company in charge of creating this brain booster, shows that you will notice the following changes when you use the Qualia Mind supplement. 

  • Your willpower to concentrate and stay focused is increased by 85%.
  • You will be able to plan better as planning skills increase by 37.2%
  • Visual representation skill is also jacked up by up to 31.1%
  • Additionally, verbal reasoning receives an increase of 16.9%
  • And there is a 13.3% boost in verbal short-term memory.

Ingredients list

There are 25 ingredients used in the making of Qualia Mind, and the ingredients here can be grouped into amino acids, vitamins, and herbs:

  • Bacopa monnieri leaf extract 
  • Rhodiola Rosea root extract 
  • DL-Phenylalanine 
  • Uridine-5′-Monophosphate heptahydrate disodium 
  • N-Acetyl-L-Tyrosine
  • Taurine
  • L-Theanine
  • Alpha-Glycerylphosphorylcholine (Alpha GPC)
  • Cognizin
  • Organic Coffeeberry (caffeine) 
  • Whole Coffee (Coffea arabica)
  • Velvet Bean (Mucuna pruriens)
  • Phosphatidylserine (sunflower lecithin) 
  • Theobromine
  • DHA (as Docosahexaenoic Acid from Algae)
  • Celastrus paniculatus Seed Extract 
  • Ginkgo biloba Leaf Extract (24% glycosides)
  • Coleus forskohlii Root Extract (20% forskolin) 
  • Pyrroloquinoline Quinone disodium 
  • Huperzia serrata Leaf Extract (7% Huperzine A) 
  • Artichoke leaf extract 
  • Acetyl-l-carnitine HCI 
  • Thiamine 
  • Niacin 
  • Pantothenic acid 
  • Vitamin B6 
  • Vitamin B12 
  • Vitamin C (ascorbic acid) 
  • Vitamin D3

You might like to know that some of your professional and public figures have shown their support and commended the effectiveness of the Qualia Mind pill. Some include Jason Silva, host of Brain Games on National Geographic, Ben Greenfield, and Dr. Daniel Stickler.

Side Effects and Precautions

Qualia Mind is not recommended to be used by breastfeeding and pregnant women. It has a few side effects attributed to the impact of caffeine ingredients, Huperzine-A and N-acetyl-L-Tyrosine. It should also not be taken very close to bedtime since it can induce restlessness. 

Unlike other nootropics, you will have to take up to 7 pills per day to get the full effect. This might seem too much to someone who dislikes taking pills. 

Altogether, it is advised to get the go-ahead from a medical professional before using the Qualia mind cognitive enhancer.

Check Price for Qualia Mind!


5. BrainPill

Brain Pill Pack

Being new to the natural nootropics supplements scene doesn’t take away the effectiveness and cognitive enhancing abilities of BrainPill.

If you are a workaholic and have very little time to rest, this nootropic stack is for you.

This cognitive enhancer is also recommended for people struggling with cognitive decline who tend to forget things easily.

BrainPill can quickly help you with your focus levels and avoid distractions. It ensures your brain gets the nutrients it needs and helps make learning new things easy while taking care of brain fog issues.

Just like Qualia’s mind, BrainPill comes with a celebrity endorsement of its own. One public figure that endorses Brainpill’s use is Champion Ken Jennings, the winner with the longest winning streak in the Jeopardy TV game.

Ingredients List

  • Citicoline
  • Synapsa
  • Bacopa monnieri
  • Folic Acid
  • Phosphatidylserine
  • DHA complex
  • Huperzine A
  • BIoperine
  • Vinpocetine
  • Huperzia Serrata
  • Pantothenic Acid
  • Ginkgo biloba
  • Vitamin B6
  • L-Theanine
  • Vitamin B12

This stack of nootropic ingredients makes the BrainPill supplement capable of improving learning and memory function. An overdose can lead to diarrhea, Insomnia, and headache. To enjoy the full effects of the BrainPill, it is recommended you play puzzles.

Check Price for Brain Pill!


6. Alpha Brain

Alpha Brain bottle

The Alpha Brain nootropic supplement is the only one on this list available in powder form and a capsule package.  Those forms make for easy consumption.

This nootropic supplement was created in 2011 to foster alpha waves’ production and increase the brain’s neurotransmitters’ numbers. Think of it as a ‘super’ nootropics.

With Alpha Brain powder, you don’t need to wait for hours before the Alpha Brain supplement hits you. In this form, the supplement goes straight to your bloodstream and then to the brain.

Just mix it with water, and you are good to go. It is also suitable for people who dislike swallowing drugs.

The capsule form of the Alpha Brain contains the same ingredients as the Alpha powder. The only difference is that it takes a longer time before you feel the effects. Your body will first have to break the vegan capsules before absorbing the nutrients.

Among the many benefits Alpha brain offers, some include

  • Heightened mental clarity
  • 6 hours of cognitive boost
  • Mental recall and verbal processing go off the roof.


  • L theanine and L tyrosine
  • Cat’sCat’s claw extract
  • Alpha GPC
  • Pterostilbene
  • Phosphatidylserine
  • L leucine
  • Huperzia Serrata
  • Bacopa Monnieri
  • vitamin B6
  • Maltodextrin
  • Vegetarian capsule
  • Rice hull concentrate

The Alpha Brain supplement has a few side effects, but these side effects are rare. Nausea, headache, vivid dreams, jaw pain, and difficulty sleeping are known side effects.

Check Price for Alpha Brain!


What is the closest thing to

over the counter Adderall?

When it comes to speed and effectiveness, no over-the-counter nootropic supplement comes close to Adderall. But for this question, the closest over-the-counter nootropic supplements you can use are Mind lab pro and the Brain pill supplement.

Not only are they available over the counter and very effective in boosting cognitive function. Unlike Adderall, you do not have to worry about side effects from long-term use.

The brain-boosting supplements discussed here are of tremendous health benefits. They speed up memory function, growth, and repair of brain cells, improve focus and increase blood flow to the brain. Additionally, users experience zero or only mild side effects, making them safe for long-term use, unlike prescription brain pills recommended for only short-term use.

Before you dive into using any Nootropic, natural or synthetic, carry out your research on nootropic ingredients and get a medical expert to provide you with medical advice.

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