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The effects of aging have us all looking for the proverbial fountain of youth. SeroVital HGH and many other pharmaceutical companies claim to have produced just that in the form of human growth hormone (HGH) releasers.

As America’s number one anti-aging supplement, SeroVital claims to turn back time and leave you feeling and looking younger than ever before.

Is there substance to their assertions, or are they marketing snake oil? In this SeroVital review, we answer your most burning questions and investigate how the alternatives measure up.

SeroVital HGH First Look

Here’s a quick round-up of the stand-out points of SeroVital HGH.

What We Like

  • All-natural ingredients
  • Proven to increase HGH levels
  • Noticeable results within 3 months
  • Advanced version available for added benefits
  • 30-day money-back guarantee
  • Comes in capsules or as a liquid concentrate
  • Simple dosage instructions
  • Patented and FDA regulated

What We Don’t Like

  • Slightly more expensive than alternatives
  • Each dose requires 4 capsules to be taken

Bottom Line

SeroVital is a trusted HGH releaser supplement used by thousands around the world. The product is FDA regulated and has very few side effects when taken according to the instructions. SeroVital HGH offers benefits such as increased energy, healthier skin, better sleep, and increased libido.

Reviews are generally positive, and there are no contraindications provided use of the product is cleared with a doctor first.

Find the best price for SeroVital HGH.

What Is SeroVital HGH?

SeroVital HGH is a self-proclaimed ‘Renewal Complex’ dietary supplement used mainly by women to encourage healthy aging through improving sleep quality, strengthening bones, increasing energy levels, and reducing the appearance of wrinkles.

It claims benefits such as:

  • Improved mood
  • Better sleep
  • Lean muscle mass gain
  • Softer wrinkles and fine lines
  • Reduction of body fat
  • Stronger bones
  • Increased sex drive
  • Smooth skin
  • Weight loss

SeroVital acts as an anti-aging amino acid formula that promotes natural production of HGH. The HGH deficiency created as we grow older results in sagging skin, loss of muscle mass, and a lack of energy. SeroVital works to counter this drop and reverse the signs of aging in both men and women.

It now comes in both capsules and a liquid concentrate.

What Is the Human Growth Hormone (HGH)?

HGH, or somatotropin, is a peptide hormone essential for growth and development. Produced in the pituitary gland, it encourages cell reproduction and regeneration, primarily to drive growth in children and teenagers [1].

Secondary functions include the regulation of body fluids, muscle development, bone growth, and the metabolism of fats and sugars.

Initially prescribed to young patients experiencing growth stunts, the benefits of HGH for adults were discovered in clinical trials soon after. These included countering conditions such as insulin resistance, weight gain, and early-onset osteoporosis [2].

GH treatment had positive results on body bone mineral content in women with postmenopausal osteoporosis

HGH for women is touted as the youth hormone due to its proclaimed ability to help slow down the signs of aging.

SeroVital HGH Ingredients

SeroVital dietary supplements do not include any form of synthetic HGH. Unlike HGH injections, it doesn’t directly introduce the human growth hormone into your body. Instead, the supplement consists of a patented blend of five concentrated amino acids and one powdered herb aimed at increasing the natural HGH production rate.

The proprietary recipe consists of the following:


As the most prevalent amino acid in the bloodstream, L-Glutamine plays an important role in protein synthesis and is essential for lean muscle mass maintenance.

It may also increase HGH production as even as little as 2 grams of L-Glutamine led to elevated HGH levels in test subjects. [3]

L-Arginine Hydrochloride

L-Arginine is widely believed to increase the production of HGH in adults. Many personal accounts of its effects seem to support the assumption, however, studies conducted have not been able to conclusively prove the correlation between L-Arginine intake and higher levels of HGH in the blood [4].

L-Lysine Hydrochloride

Small volumes of L-Lysine Hydrochloride combined with L-Arginine have been recorded to raise HGH levels in the bloodstream. Its long-term effects are unknown, and its ability to trigger HGH production by itself remains inconclusive [5]. The amino acid does, however, aid in anxiety relief and benefits the bones and skin.


Oxo-Proline is a derivative of the glutamic amino acid. Anecdotal evidence has shown it may assist the improvement of cognitive functions like memory, creativity, and motivation, although this has not yet been scientifically verified [6].

N-Acetyl L-Cysteine

The main benefit obtained from N-Acetyl L-Cysteine supplementation is its use in the production of antioxidants [7]. Antioxidants protect and repair cells, which in turn may result in the softening of wrinkles and pigmentation by regenerating skin cells.

Schizonepeta Powder

Also known as Japanese Catnip, Schizonepeta is an anti-inflammatory herb native to China [8]. Although it does not have a proven effect on HGH production, anecdotal evidence suggests its properties are beneficial to the skin.

SeroVital vs SeroVital Advanced

SeroVital is commonly referred to as the original ‘Renewal Complex.’ It costs $99.00 for a month’s supply.

SeroVital Advanced includes the proprietary blend of amino acids in the original as well as a separate morning blend of herbs and supplements to improve digestion and focus levels, hydrate the skin, and kickstart your metabolism. It costs $119.00 for a box, equal to one month’s supply.

Unlike the original SeroVital, the advanced product may provide results from the first month and has been gaining popularity over recent years.

The additional Advanced blend ingredients include:

  • Wild mint leaf extract – an anti-inflammatory that also aids digestion
  • Collagen and keratin peptides – they benefit the skin and hair respectively
  • Olive leaf extract – may lower blood pressure and support weight loss
  • Hyaluronic acid – for skin rejuvenation and repair [9]
  • Lady’s Mantle leaf extract – may aid in regulating menstruation
  • Coffee bean extract – the caffeine it contains may increase energy levels and reduce the appetite
  • Glucomannan – regulates the metabolism and enables weight and body fat loss
  • Cumin seed extract – high in antioxidants and may help manage blood pressure
  • Chlorella – may have antioxidant, anti-viral, and anti-bacterial properties, but conclusive research is not yet available

The second set of ingredients, consisting mainly of vitamins and minerals, is included to either help increase HGH levels or provide independent anti-aging benefits.

These include:

Vitamin C (as ascorbic acid)

Vitamin C is a powerful antioxidant that fights free radicals responsible for premature skin aging and is essential for collagen production.

Vitamin D (as cholecalciferol)

One of the most widely used ingredients in anti-aging supplements, Vitamin D protects against pigmentation and fine lines resulting from sun exposure and is crucial for maintaining bone strength [10].

Riboflavin (Vitamin B2)

Riboflavin is involved in the breakdown of nutrients and plays an important part in preserving the body’s energy reserves. It may help users feel more energized.

Zinc (as zinc gluconate)

Zinc aids in collagen production which helps keep skin looking younger. Zinc is also necessary for preventing several age-related diseases by boosting the immune system [11].

Selenium (as l-selenomethionine)

Selenium also helps fight against diseases associated with aging [12]. It assists in the neutralization of free radicals associated with wrinkle formation as well.

Copper (as copper gluconate)

Copper is necessary for improving skin elasticity and reducing the appearance of fine lines, pigmentation, and wrinkles [13]. It may also help prevent hair loss.

The group sleeping with a copper pillowcase saw a 9.84% decrease in fine lines compared to the 0.59% reduction experienced by the placebo group

Does SeroVital Work? Real SeroVital HGH Reviews

Some skepticism exists over whether or not SeroVital lives up to its reputation. The most widely quoted study where subjects taking the SeroVital capsules experienced an average 682% increase in HGH levels was, after all, conducted by the company itself.

The customer reviews below may help you draw the correct conclusion of SeroVital’s effectiveness.

One user stated the following:

Although marketed to women, a male reviewer reported a positive impact on his overall wellbeing:

Not all reviews were raving over the success of the product, however, as some users still struggled to lose weight.

Another critical review stated the following:

As with many natural supplements, not everyone can expect the same results.

How To Take SeroVital HGH

The two versions of SeroVital require slightly different dosage schedules as the Advanced version contains two extra tablets to be taken daily.

Standard Dosage

A daily dose of the original SeroVital blend consists of four capsules. These can be taken at any time of the day on an empty stomach. You shouldn’t eat or drink anything other than water for at least two hours before and two hours after taking SeroVital.

Advanced Dosage

A daily dose of SeroVital Advanced consists of four capsules and two tablets. The red and white tablets make up the morning blend and should be taken with or without food.

The four yellow capsules of the original Renewal Complex should be taken in the evening on an empty stomach. Avoid eating or drinking anything except water for two hours before and after this dose.

Who Shouldn’t Take SeroVital HGH?

No contraindications for taking SeroVital are listed. However, pregnant women and individuals with chronic illnesses who may be affected by any of the ingredients should consult their doctor before taking SeroVital or SeroVital Advanced.

What Are the Side Effects of SeroVital HGH?

The possible side effects of SeroVital mainly stem from the active ingredients in the product, specifically the amino acids.

These include:

  • Nausea
  • Vomiting
  • Stomach pain
  • Diarrhea
  • Bloating
  • Constipation
  • Water retention
  • Swelling of hands and feet
  • Gout

The ingredients of SeroVital are all-natural, and the product line is both patented and FDA regulated. These side effects are only likely to occur in the case of an overdose.

SeroVital Alternatives

The alternatives to SeroVital come in many forms, from doctor-prescribed injections to topical gels. One HGH gel, known as Somaderm, claims many of the same benefits as SeroVital, including improved sleep, more energy, and increased libido. Our full Somaderm review provides intriguing insights into the power of the product.

Orally administered alternative dietary supplements include:

Tru Niagen

Tru Niagen contains active ingredients that stimulate the creation of NAD+, a coenzyme that aids cell repair and defense, over time enabling your body to counter factors like stress, sun exposure, and restless sleep [14].

  • $47.00 for a 30 day supply
  • One 300mg capsule taken daily
  • 30-day refund policy if the product is unused
  • Promotes healthy aging, increases cellular energy, and encourages cellular defense and repair

Although well-received and proclaimed effective by its users, Tru Niagen does not offer the full range of benefits claimed by SeroVital.


Nugenix GH-Boost asserts itself as a human growth hormone release trigger, as well as providing support of endocrine balance and improving sleep quality. Its ingredients are similar to that of SeroVital and partly consist of a mixture of amino acids.

  • $79.99 for a 30 day supply
  • 1 berry-flavored sachet dissolved in water to be taken at night
  • No listed return policy, but if bought through affiliates this may be possible
  • Improves mood, supports the endocrine system, enables quality sleep, prevents cortisol levels from rising under stress, and acts as a growth hormone amplifier

The product is not regulated by the Controlled Substances Act and, although many people who have used Nugenix claim it has improved their energy levels, sleep quality, and helped them lose weight, there is no scientific evidence to back them. Our in-depth Nugenix review provides more detail about how this product works.


GenF20 is a dietary supplement that purportedly promotes the natural secretion of the human growth hormone.

  • $79.95 for a 30 day supply
  • 2 tablets one hour before lunch, and 2 tablets one hour before dinner
  • 67-day money-back guarantee if the product does not increase HGH levels
  • Encourages healthy loss of body fat, lean muscle mass gain, improved stamina, faster metabolism, improved sex drive, reduction of wrinkles, higher energy levels

As another alternative made from similar amino acids as SeroVital, the effectiveness and long-term benefits of GenF20 cannot be quantified as only one clinical trial has been conducted.


The information available on SeroVital HGH may at times seem overwhelming. Some of the most frequently asked questions and their answers can be found below.

Does SeroVital Have a Money Back Guarantee?

Yes, if you are not completely happy with the supplement, SeroVital offers a hassle-free money-back guarantee. Simply contact their Customer Service Center within 30 days of receiving the product and request a refund.

Once what is left of the product is returned (with free return shipping in the US), SeroVital will issue a refund to the original payment method within five days.

Is It Safe To Take SeroVital?

Yes, it is safe to take SeroVital. All the ingredients are natural, consisting only of amino acids and herbs, so the supplement is safe as long as the recommended daily dosage is adhered to.

Most side effects will only appear in the case of an overdose. This usually occurs when the user takes double the recommended amount to make up for a missed dosage.

Should you stop using SeroVital, the symptoms of HGH withdrawal are important to note. As the production rate slows and your HGH levels return to normal, you may experience drowsiness, depression, and irritability [15].

How Long Does It Take To See Results From SeroVital?

As with all natural supplements, results take time. How much time differs from person to person.

SeroVital claims most women experience noticeable results within three months. Some may have to wait a little longer, while many people have reported feeling more energetic from the first week.

Is SeroVital Good For Menopause?

Although SeroVital was not specifically designed to counter the symptoms of menopause, many women have reported it helping with many of the discomforts it brings, such as hot flushes.

Despite the supplement not having any consistent effects on menopausal women, its overall benefits may provide positive results during this time.

Does SeroVital Increase HGH Levels?

An independent, investigator-initiated study completed in 2019 found that taking SeroVital every day for 24 weeks had a positive impact on the participants’ growth hormone levels.

45 adults, averaging 67 years of age, were given SeroVital as a dietary supplement for six months. From week 12, their average HGH levels began to increase and remained above the baseline for the remainder of the study [16].

Subjects taking an HGH-enhancing amino acid supplement saw a significant change in IGF-1 levels at 24 weeks



Despite many supplements manufactured to stimulate HGH release coming under scrutiny for overselling their benefits, SeroVital receives positive reviews from many users and has had at least some of its claims proven in clinical studies.

Even if SeroVital does not prove as effective in raising HGH levels as is advertised, many of its ingredients are highly beneficial to the skin, mind, muscles, and bones. As such, SeroVital provides health benefits regardless of its ability to affect the pituitary gland.

If you are in search of a supplement to help you look and feel healthier, more energized, and help turn back the clock, even if only you can feel it, SeroVital HGH may enable you to do so.



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  2. Aloia JF; Zanzi I; Vaswani A; Ellis K; Cohn SH; “Combination Therapy for Osteoporosis.” Metabolism: Clinical and Experimental, U.S. National Library of Medicine,
  3. Welbourne, T C. “Increased Plasma Bicarbonate and Growth Hormone after an Oral Glutamine Load.” OUP Academic, Oxford University Press, 1 May 1995,
  4. MH;, Fogelholm GM;Näveri HK;Kiilavuori KT;Härkönen. “Low-Dose Amino Acid Supplementation: No Effects on Serum Human Growth Hormone and Insulin in Male Weightlifters.” International Journal of Sport Nutrition, U.S. National Library of Medicine,
  5. M;, Isidori A;Lo Monaco A;Cappa. “A Study of Growth Hormone Release in Man after Oral Administration of Amino Acids.” Current Medical Research and Opinion, U.S. National Library of Medicine,
  6. Sasaki, Shotaro, et al. “Functional Characterization of 5-Oxoproline Transport via SLC16A1/MCT1.” The Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 23 Jan. 2015,
  7. Terluk MR;Ebeling MC;Fisher CR;Kapphahn RJ;Yuan C;Kartha RV;Montezuma SR;Ferrington DA; “N-Acetyl-L-Cysteine Protects Human Retinal Pigment Epithelial Cells from Oxidative Damage: Implications for Age-Related Macular Degeneration.” Oxidative Medicine and Cellular Longevity, U.S. National Library of Medicine,
  8. Kim SJ;Kim JS;Choi IY;Kim DH;Kim MC;An HJ;Na HJ;Kim NH;Moon PD;Myung NY;Lee JY;Jeong HJ;Um JY;Shin TY;Kim HM;Hong SH; “Anti-Inflammatory Activity of Schizonepeta Tenuifolia through the Inhibition of MAPK Phosphorylation in Mouse Peritoneal Macrophages.” The American Journal of Chinese Medicine, U.S. National Library of Medicine,
  9.  Bukhari SNA; Roswandi NL; Waqas M; Habib H; Hussain F; Khan S; Sohail M; Ramli NA; Thu HE; Hussain Z; “Hyaluronic Acid, a Promising Skin Rejuvenating Biomedicine: A Review of Recent Updates and Pre-Clinical and Clinical Investigations on Cosmetic and Nutricosmetic Effects.” International Journal of Biological Macromolecules, U.S. National Library of Medicine,
  10. M; Mitsuo T; Nakao. “[Vitamin D and Anti-Aging Medicine].” Clinical Calcium, U.S. National Library of Medicine,
  11. Cabrera, Ángel Julio Romero. “Zinc, Aging, and Immunosenescence: an Overview.” Pathobiology of Aging & Age Related Diseases, Co-Action Publishing, 5 Feb. 2015,
  12. H; Cai Z; Zhang J; Li. “Selenium, Aging and Aging-Related Diseases.” Aging Clinical and Experimental Research, U.S. National Library of Medicine,
  13. Borkow, Gadi. “Using Copper to Improve the Well-Being of the Skin.” Current Chemical Biology, Bentham Science Publishers, Aug. 2014,
  14. E;, Covarrubias AJ;Perrone R;Grozio A;Verdin. “NAD + Metabolism and Its Roles in Cellular Processes during Ageing.” Nature Reviews. Molecular Cell Biology, U.S. National Library of Medicine,
  15. McMillan CV; Bradley C; Gibney J; Healy ML; Russell-Jones DL; Sönksen PH; “Psychological Effects of Withdrawal of Growth Hormone Therapy from Adults with Growth Hormone Deficiency.” Clinical Endocrinology, U.S. National Library of Medicine,

Pekarovics, Susan, et al. “SUN-439 Improvement in Insulin-Like Growth Factor-1 and Clinical Symptoms: Results of an Open-Label, Single-Arm Study of a Human Growth Hormone-Enhancing Amino Acid Supplement.” OUP Academic, Oxford University Press, 30 Apr. 2019,

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